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Herbal Therapy Against Pulmonary Diseases In Pig And Man With Typhonium Trilobatum Schott (L.) Schott. An Indian Medicinal Plant
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| Author:
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PREMANANDA DAS, DHANESWAR SWAIN, GYANA DAS, DEVENDRA KUMAR MARAVI, SEEMA RANI PEGU, SWARAJ RAJKHOWA, DILIP KUMAR SARMA, RACHITA SARANGI, DEBASMITA DUBEY, PRADEEP KUMAR NAIK
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| Abstract:
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Respiratory tract infections are common ailments in man and pig. Several species of bacteria are associated with the infection. Considering the uses of Typhonium trilobatum(L.) in both Unani and Ayurvedic medicinal systems, we approached to investigate its efficacy against selected respiratory tract bacterial pathogens associated with both man and pig. The tuber extract was prepared using hydro-ethanol (80:20). Different phytochemicals present were characterized based on GC-MS and NMR. Bacteria species were isolated and identified from the nasal swabs and tissues samples of patients and pigs suffering from respiratory disease. The antibacterial activity of the extract was evaluated using agar well diffusion and micro-broth dilution method to determine the MIC and MBC. Further, the efficacy of the extract was tested by monitoring the complete recovery of the pigs suffering from respiratory disease. Hydro-ethanolic extracts of T. trilobatum showed significant antibacterial activity with the bacterial flora isolated from both the patients and pigs. Experimental animals suffering from flu-like symptoms recovered in 3-6 days with oral supplements of 500-300 mg/mL/day/pig. The antibacterial efficacy of the hydro-ethanolic extract can be attributed to the presence of three broad groups of compounds such as organic acids, monosaccharides and polyols as detected by GC-MS. This study validated the antibacterial properties of T. trilobatum tuber extract against bacterial flora isolated from patients and pigs causing respiratory tract infections. Also, the animals were found free from flu-like symptoms without any adverse reaction with the oral supplement of the extract.
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| Keyword:
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Typhonium trilobatum, pulmonary diseases, multidrug-resistant bacteria, GC-MS, NMR, in vitro and in vivo studies.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.496
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| Download:
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