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New Insights into Pathogenesis and Immunity of Leishmania Parasites with Emphasis on Vaccines
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| Author:
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AISHAH E ALBALAWI, MOHAMED S ALYOUSIF, ABDULLAH D ALANAZI, GHAZAL SHAHROKHI, MARYAM SEPAHVAND, HOSSEIN MAHMOUDVAND, MOHAMMAD REZA NAZER
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| Abstract:
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Leishmaniasis is an important group of vector-borne diseases that caused by genus of Leishmania and affect
both humans and animals. In this study it has been attempted to review the factors that involved in
pathogenesis of Leishmania, immune responses against Leishmania, and the vaccines used in treatment of
Leishmania infection. Here we discussed about Leishmania surface molecules–parasite factors
(lipophosphoglycan, glycoprotein 63, protein disulfide isomerase, promastigote secretory gel, arginase) in
pathogenesis, attachment and entry of parasites to host cells, and host immunity (Neutrophil, macrophages, T
and B cells, etc) against Leishmania parasites. The treatment against leishmaniasis are limited with the use of
pentavalent antimonials, amphotericin B, etc. But because of the toxicity and high cost of these drugs, the
development of effective vaccines is very desirable and efficient. Here we reviewed the new findings about first
(Leishvaccine), second (Leishmune, Canileish, and Leish-tech) and third-generation vaccines against
leishmaniasis.
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| Keyword:
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Leishmaniasis, vaccination, treatment, immunotherapy, immune response
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.485
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| Download:
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Request For Article
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