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Effect of Naringenin on streptozocin induced Diabetes in rats
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UPLOADED BY-ADMIN, RAJENDRAPRASAD KALUVALA, VELAYUTHAM SURESH, A. SURESH, G.ARUNACHALAM
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| Abstract:
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Naringenin is a flavonone mostly present in Grape fruits that is considered to have a bioactive effect on human health as
antioxidant, radical scavenger, antiinflammatory, carbohydrate metabolism promoter, and immunity system modulator. The
current investigation is to study the antidiabetic activity of citrus bioflavonoid Naringenin on Streptozotocin induced
diabetes in rats. Male albino Wistar rats weighing about 150–180 g were grouped into 5groups comprising of 6 animals in
each. We investigated the effect of Naringenin on biochemical parameters such as Blood Glucose, Urea, Uric acid and
Creatinine in streptozotocin-induced (STZ - 55 mg/kg, single i.p. in 0.1M citrate buffer pH 4.5) diabetic rats. All the grouped
data was statistically evaluated via the Statistical Package for Social Sciences version 14.0 and one way analysis of variance
(ANOVA) followed by least significant differences test. p-values of less than 0.05 were considered to indicate statistical
significance. All the results were expressed as mean ± SD for six animals in each group. The Naringenin (5mg/kg, i.p,)
decreased the hyperglycemia associated with STZ-diabetes. Naringerin treatment prevents STZ-induced changes in the
activities of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and Alkaline phosphatase (ALP) in the
liver indicating the protective effect of naringerin against the hepatotoxicity caused by STZ. The Naringenin can improve the
glucose, Urea, Uric acid and Creatinine activities and is beneficial in preventing diabetic complications. Therefore,
Naringenin has a protective effect against the hepatotoxicity produced by STZ-diabetes.
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Citrus bioflavonoids, Naringenin, Hypoglycaemic activity, Streptozotocin, Alkaline phosphatase, Alanine aminotransferase.
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