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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis, Characterization, Antimicrobial, AntiInflammatory and Anti-Diabetic Activity Studies on Metal (II) Complexes Derived from 4-(2-AMINO ETHYL) BENZENE-1, 2-DIOL and BUTANE-2, 3-DIONE

Author: T GOMATHI, S KARTHIK, S VEDANAYAKI
Abstract: A novel Schiff base ligand (L) was synthesized using 4-(2-amino ethyl) benzene-1, 2-diol (Dopamine) and butane - 2, 3-dione. Co(II), Ni(II), Cu(II) and Zn(II) complexes with this hexadentate ligand were synthesized with metal: ligand stoichiometry 1:1. The Schiff base ligand and its metal complexes have been characterized by elemental analysis, molar conductance, magnetic susceptibility, IR, electronic spectra, ESR, NMR, Mass spectra and SEM studies. Molar conductance showed that all complexes are non-electrolytic nature. Different morphologies of synthesized compounds were identified by SEM images. Schiff base ligand and its metal complexes were screened against gram-positive bacteria, gram-negative bacteria and one fungus strain. The data shows that the ligand and its metal complexes have significant activity. Copper(II) complex shows better activity than other complexes. The Schiff base ligand and its copper(II) complex were evaluated for the antiinflammatory by HRBC membrane stabilization method. The anti-diabetic activity of Schiff base ligand and its copper(II) complex was also studied by the Alpha-amylase method
Keyword: Schiff base, molar conductance, ESR, anti-diabetic
DOI: https://doi.org/10.31838/ijpr/2021.13.03.004
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