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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Hepatoprotective Potential of Methanolic and Aqueous Leaves Extracts of Swietenia Mahagoni Linn in Paracetamol and CCl4 induced Hepatotoxicity Models

Author: KOLA VENU, LAXMAIAH CH, DIPTENDU BHOWMIK, SANTHOSH KUMAR CHINNAIYAN, CHIRANJIB BHATTACHARJEE
Abstract: The present research was performed to estimate both the phytochemistry and pharmacological potential of Swietenia mahagoni leaves in validated animal models. The shade dried and powdered leaves were extracted with different organic solvents and after successive extraction, the aqueous extract was subjected to preliminary phytochemical study for identification of various phytochemicals. The fixed-dose method for acute toxicity was performed following the OECD guidelines 420. The hepatoprotective property of the aqueous and methanolic extracts was studied against paracetamol and carbon tetrachloride models in rats. Groups that are treated with aqueous, methanolic extracts and Silymarin depicted an important restoration of wet liver volume and weight near to its normal conditions. Toxic effects produced by carbon tetrachloride and paracetamol were significantly controlled with both the extracts by restoration of levels of the biochemistry of liver function, with that of standard silymarin. The toxicant decreased Catalase and SOD activities of the liver. The histopathological changes like necrosis, and fatty changes (steatosis), etc were fully or partly prevented in treated animals using extract. The results are due to the presence of flavonoids, alkaloids, saponins, steroids, tannins, and glycosides in both the extracts are responsible for hepatoprotective activity. A dose-dependent hepatoprotective effect was produced with both the extracts.
Keyword: Swietenia mahagoni, Hepatoprotective, Silymarin, Paracetamol, Carbon Tetrachloride
DOI: https://doi.org/10.31838/ijpr/2021.13.03.071
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