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Development, Characterization and In-Vitro/Ex-Vivo Evaluation of Mucoadhesive Microsphere of Sumatriptan Succinate For Nasal Delivery
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| Author:
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RUJUTA P. MISTRY, DRASHTI A. MANDALE, DR.NIDHI N.CHAUHAN
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| Abstract:
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The present research work was aimed at development and evaluates of poly lactic co-glycolic acid (50:50) mucoadhesive microspheres of Sumatriptan Succinate for nasal delivery to avoid first pass metabolism and to improve the therapeutic efficacy in the treatment of Migraine. The microspheres were prepared by a spray drying technique. Particle size was analyzed by optical microscope technique and found to be in the range of 12-30 µm, which is favorable for intranasal absorption. The shape and surface characteristics were determined by scanning electron microscopy (SEM) which depicted the spherical nature and possess smooth surfaces of the microspheres. The percentage encapsulation efficiency was found to be in the range between 94-100%. In vitro mucoadhesion was carried out using sheep nasal mucosa and result obtains in 76.11-97.12. Differential Scanning Colorimetry, result indicated a molecular level dispersion of Sumatriptan Succinate in the microspheres. In vitro release studies in pH 6.2 phosphate buffer indicated anomalous transport mechanism for drug release of Sumatriptan Succinate from the microspheres. On the basis of these results, Sumatriptan Succinate loaded PLGA microspheres may be considered as a promising nasal delivery system.
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| Keyword:
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Drug Release, Incorporation Efficiency, Poly Lactic Co Glycolic Acid, Particle Size, Swelling Index
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.03.060
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| Download:
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