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Self-Emulsifying Drug Delivery System: A Technique to Improve Oral Bioavailability of Poorly Soluble Drugs
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| Author:
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SHIVANI, RITIKA PURI
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| Abstract:
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As oral drug delivery system is problematic for the drugs which are deprived of solubility in aqueous solutions. Around 40% of new drug candidates coming in the market have low water solubility, and oral administration of such drugs is often correlated with low bioavailability, high intrasubject variability, and dose proportionality issues. Dissolution of hydrophobic or lipophilic drugs into the microemulsions and encapsulation in the form of fine globules followed by absorption in the intestine by avoiding the dissolution stage, limits the rate of absorption of hydrophobic drugs. Delivery of poorly soluble drug is slowed down where dissolution is the rate limiting step. It gives exposure to a novel drug delivery system to improve the poor solubility as well as low bioavailability. The various strategies have been come out into literature such as solid dispersions, eutectic mixtures, complexation, permeation enhancers, use of surfactants and self-emulsifying drug delivery system (SEDDS). Self-emulsifying drug delivery systems have been reported to increase the oral absorption mainly of lipophilic drugs. This review focuses on excipients required in the preparation of SEDDS, mechanism of self-emulsification along with invitro-characterization.
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| Keyword:
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SEDDS, GRAS, lipophilic, Bioavailability, oral drug delivery, poor solubility
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.03.120
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| Download:
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