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RP-HPLC Method Development and Validation for Simultaneous Determination of Deflazacort and Tamsulosin Hydrochloride
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| Author:
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KANNA LAXMI SIDRAM, TAMBOLI ASHPAK MUBARAK
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| Abstract:
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The RP-HPLC method was used to develop and validate a simultaneous estimation of Deflazacort and Tamsulosin hydrochloride in combined dosage form. Using the RP-HPLC procedure, the linearity ranges for Deflazacort and Tamsulosin hydrochloride are 180-420 g/ml for Deflazacort and 2.4-5.6 g/ml for Tamsulosin hydrochloride, with co-relation coefficients of 1.000 for both products.The percentage recovery for Deflazacort was 99.89% and for Tamsulosin hydrochloride was 99.78%. The LOD values for Deflazacort and Tamsulosin hydrochloride was found to be 2.34 g/ml and 0.04 g/ml, respectively. The LOQ values for Deflazacort and Tamsulosin hydrochloride was 7.11g/ml and 0.13g/ml, respectively.The assay results for Deflazacort and Tamsulosin hydrochloride were 100.14 and 100.27 percent comparable, showing strong label conformity.
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| Keyword:
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Any of the keywords used in this analysis are Deflazacort, Tamsulosin hydrochloride, RP-HPLC, and Validation.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.03.168
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| Download:
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