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Review on potency of encapsulated and unencapsulated form of vitamin C produced from agricultural wastes against acute and chronic wound healing
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| Author:
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KAVIYALAKSHMI M, DR.M.MEKALA
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| Abstract:
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Vitamin C, water soluble vitamin acts as essential element in healing of acute and chronic wounds. Acute wounds include the traumatic wound and burns caused by heat, cold and electricity, which progress through the normal stages of wound healing and heals completely within four weeks, while chronic wounds do not progress normally through the stages of healing and do not show evidence of healing within four weeks. Healing wounds with synthetic ointments results in side effects including pain, burning, itching, rashes, and sticky on the surface of wound. To overcome these effects, naturally produced vitamin C using agricultural wastes (vegetable and fruit peels) with microorganisms by Reichstein-Grussner fermentation process. Vitamin C accumulates in phagocytic cells, such as neutrophils, and can enhance chemotaxis, phagocytosis, generation of reactive oxygen species, and results in microbial killing. Also, involved in collagen synthesis by hydroxylation of proline and lysine residues, important for conversion of procollagen. Application of vitamin C solution directly on wound enhances healing but shows a limitation of poor absorption capacity since they are water soluble. The encapsulation technique protects the vitamin from outside environment and results in controlled in release on the wound. The review discusses about the process of wound healing and effect of topical of formulation of encapsulated and unencapsulated vitamin C.
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| Keyword:
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wound healing, vitamin C, nutrition deficiency, microorganisms, agricultural wastes, neutrophils, collagen, encapsulation
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.03.127
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| Download:
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Request For Article
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