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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Evaluation of the Anti-Snake Venom Activity of Flavonoids from the Root Bark Extract of Parinari Curatellifolia in Mice

Author: UPLOADED BY-ADMIN, SIMEON OMALE, ASA AUTA, KENNEDY I. AMAGON, MRIOSE V. IGHAGBON
Abstract: Snake bites constitute a major public health problem worldwide. This research was carried out to evaluate the flavonoids isolate of the root bark extract of Parinari curatellifolia for anti-snake venom activity. Flavonoids were isolated from the root bark of Parinari curatellifolia by fractionation and the LD50 of the flavonoid extract was determined. Groups of 5 mice each were pre-treated with the minimum lethal dose of venom (2.25 mg/kg) before the administration of graded doses of the flavonoid extract of the root bark of Parinari curatellifolia. The results revealed that the LD50 of the Flavonoid fraction of the P. curatellifolia was 948mg/kg. The flavonoid extract of the root bark of P. curatellifolia (at a dose of 237 mg/kg) was found to offer significant (P < 0.05) protection against Echis carinatus venom at 10 minutes and 30 minutes after pretreatment with the venom. The extract (237 mg/kg) did not show significant anti-snake venom activity at 60 minutes after pretreatment with the venom. This study therefore demonstrated that flavonoids isolated from the root bark of Parinari curatellifolia possessed anti-snake venom activity and can serve as an important source of a lead compound for the synthesis and production of anti-snake venom.
Keyword: Anti-snake venom activity, flavonoids, Parinari curatellifolia.
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