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Vitamin K Epoxide Reductase Complex, Subunit 1 Gene-1639 Polymorphism in Surakarta, Indonesia and South East Asia.
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| Author:
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T.D. ARDYANTO, R.NIRURI, A.PANGASTUTI, H.ARIFIANTO
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| Abstract:
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Vitamin K Epoxide Reductase Complex, Subunit 1 (VKORC1) Gene -1639 polymorphism was significantly associated with warfarin maintenance dose. Frequency of VKORC1-1639 variant alleles/ genotypes differed among ethnicities and populations. Genetic frequencies varied in different geographical areas. This study aimed to identify allele / genotype frequencies of VKORC1 gene -1639 in Surakarta and in Southeast Asia. The genotypes in Surakarta were identified by polymerase chain reaction confronting two-pair primers. Systematic review study was conducted to identify allele/genotype frequencies in Southeast Asia. A heterozygous GA was identified as the highest percentage genotype (53 patients (50% of 106 cardiovascular patients)) in Surakarta Indonesia. Other identified genotypes in Surakarta were AA (48 subjects (45%)) and GG (5 subjects (5%)). Meanwhile, the highest percentage genotype in Bandung and Jakarta, Indonesia, was AA. A homozygous AA was also the most common genotype in Malaysia, Bangkok, Vietnam, and Singapore. The genotype frequency distribution in Surakarta, Indonesia, was different from studies conducted in Southeast Asia.
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| Keyword:
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VKORC1-1639, Surakarta Indonesia, Southeast Asia.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.355
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| Download:
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