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Antioxidant activity and hepatoprotective potential of flavonoid rich content of Alphonsea sclerocarpa leaves
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| Author:
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DOKUPARTHI SUDHEER KUMAR, T.RAMA MOHAN REDDY
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| Abstract:
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Objectives: The liver is the targeted organ in the body for xenobiotics and development of hepatoprotective
agents to maintain liver health is an absolute requisite. Since plant-based medicine gained importance due to
fewer side effects and more safety, herbal approach to develop hepatoprotective agents is still necessary. Our
present investigation is aimed to screen the antioxidant and hepatoprotective activity of Alphonsea sclerocarpa
leaves.
Methods: Paracetamol induced hepatotoxicity model, with Silymarin as standard was taken for the flavonoid
rich fraction of A. sclerocarpa. Hematological and histopathological studies were performed. To support this
investigation, phytochemical screening, total phenolic, flavonoid, tannin contents were also determined.
Results: Results disclose that the plant was rich in polyphenolic contents and the flavonoid rich fraction is
having statistically significant (P<0.001) hepatoprotective activity in a dose dependent manner when compared
to the standard Silymarin. The biochemical and histological studies were also conducted in connection with the
titled activity and found significant to improve the abnormal blood parameters and enzymatic and nonenzymatic antioxidants in the liver tissue.
Conclusion: To clinch, all the biochemical, behavioral and histological data declared that the flavonoid rich
fraction of A. sclerocarpa is more potent among all the extracts to give protection against oxidative stress and
subsequent improvement of the physiological parameters of the liver. The antioxidant property of the
phytochemicals present in the extract may be responsible for the proclaimed activity.
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| Keyword:
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A. sclerocarpa, antioxidant, total phenolic, total flavonoid, total tannins, hepatoprotective
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.03.189
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| Download:
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