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Formulation and Evaluation of Lercanidipine Loaded Solid Lipid Nanoparticles By Design Of Experiment
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| Author:
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Y.RAMULU, D.V.R.N.BHIKSHAPATHI
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| Abstract:
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Title: Development of lercanidipine loaded solid lipid nanoparticles (SLN) and optimization by design of experiment.
Purpose: Lercanidipine is a calcium channel blocker used in treating anti-hypertension. The current research is aimed to develop SLN of lercanidipine by applying Box-Behnken design (BBD).
Methods: A design space comprising of 3 formulation variables at 3 different levels was evaluated in BBD. Lercanidipine-SLNs were prepared by hot emulsification/ultrasonication technique and evaluated for responses. Kinetic model fitting for all lercanidipine SLN formulations was done to interpret the release rate. Characterization of optimized formulation was carried out by FTIR, SEM and stability study.
Results: The optimized formulation LF15 comprising of 8% of dynasan 116 as lipid, 9% of cremophor EL as surfactant and 6% Eupikuron 200 of co-surfactant displayed 121.19% of entrapment efficiency, 99.83±2.26% of content uniformity and 98.87±2.42% of drug release. The release kinetic data suggest that drug followed zero order release mechanism. The SEM analysis confirmed spherical shape of SLN formulations. Stability studies indicated formulation was stable for 6 months.
Conclusion: The enhancement in the drug release of lercanidipine from SLNs exposed the prospective of lipid-based nanoparticles as effective carrier for enhancing the oral availability of sparingly soluble drugs.
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| Keyword:
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Lercanidipine, solid-lipid nanoparticles, Box-Behnken design, independent variables and release kinetics.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.03.200
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| Download:
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