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Potentiation of the effect of adenosine receptor blockers with beta2-adrenergic agonists in patients with bronchial hyperresponsiveness
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| Author:
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TRINGA BOZALIJA, ALI ILJAZI, ARTA DAUTI, SAUDIN MALIQI, HILMI ISLAMI
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| Abstract:
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In this study, the effect of adenosine-bamifylline receptor blockers in response to beta2 adrenergic agonist-salmeterol was studied in 18 patients with bronchial hyperresponsiveness.
Lung function parameters were determined by body plethysmography. Airway resistance (Raw) was recorded and intrathoracic gas volume (ITGV) was measured, and airway specific resistance (SRaw) and specific conductance (SGaw) were calculated.
Patients with bronchial asthma were treated on the first day with beta2 adrenergic agonist-salmeterol (2 inh x 25/µg), and then Raw and ITGV measurements were taken after 5, 30, 60, and 120 min. Salmeterol caused a significant decrease in airway resistance (p<0.05). This group of patients also served as a control. The same patients were treated with bamifylline as an adenosine receptor blocker, applied 7 days in a row at a home dose (2 x 600 mg orally). On the 8th day, two inhalations of salmeterol 25/µg spray were given to the same patient, and then Raw and ITGV measurements were made after 5, 30, 60, and 120 min. The specific resistance (SRaw) and specific conductance (SGaw) of the airways were calculated. Beta2-adrenergic agonists significantly potentiated the action of the adenosine receptors (p<0.01) and caused a decrease in SRaw and airway SGaw.
These results suggest that the effect of adenosine receptor blockers was potentiated by beta2-adrenergic receptor agonists. This confirms the conclusion that the activation of deacetylation of histones in the cell nucleus (action of xanthine substances) can reduce the transcription of some pro-inflammatory genes, while the action of xanthine is potentiated by the action of beta2-adrenergic agonists.
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| Keyword:
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Bronchial hyperactivity, adenosine-bamifylline receptors, beta2-adrenergic-salmeterol receptors.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.03.141
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