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Therapeutic plasma exchange as a promising therapeutic modality in the management of acute cytokine storms and secondary prevention of chronic kidney disease in children during pandemic
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| Author:
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, DZULFIKAR DJALIL LH, AHMEDZ WIDIASTA, RENI GHRAHANI, DANY HILMANTO, DEDI RACHMADI
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| Abstract:
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Persistent proteinuria in children is a silent killer as it potentially of being progressive severity of chronic kidney disease (CKD). Monoclonal antibodies are currently recommended for the treatment of this disease. In some developing and low socioeconomic countries, the aforementioned agents are nearly impossible to be given. Also, the COVID-19 disease has a huge impact in all countries in the world, including in nephrology and other immunocompromized patients in children. The problems caused by this disease are also exacerbated by the economic conditions of poor and developing countries. It is challenging for clinicians in poor and developing countries to take advantage of alternative modalities for the management of the disease. Therapeutic plasma exchange (TPE) is a very useful modality for the management of diseases that require clearance of proteins with a certain molecular weight. Diseases that require TPE in pediatric nephrology field is glomerular disease either related to autoimmune diseases or not. Evidence about the success of COVID-19 treatment with TPE has also been widely reported by researchers in various parts of the world. This article aims to analyze in detail the benefits of TPE in overcoming this pandemic, as well as knowing the very appropriate timing for plasmapheresis in this disease.
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| Keyword:
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Therapeutic plasma exchange, modality, acute, cytokine storm, chronic kidney disease, pandemic
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.259
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| Download:
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Request For Article
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