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Molecular Docking Studies Of Novel Benzimidazole Derivatives Against Dna Gyrase Along With Insilico Adme Studies
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| Author:
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, CHUKKA.AJAY KUMAR, CH.ARAVIND, T.GOPINADH, J.SANTHOSH EVANJALI, T.MOUNIKA, P.MOUNIKA, DR.J.N.SURESH KUMAR
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| Abstract:
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In this study, the synthesized novel Benzimidazole derivatives were taken for molecular docking simulation against 1KZN. Synthesized derivative compound structures were carried out with Mcule and Insilco ADME Prediction Procedures. The results of docking study revealed that the binding profile for all synthesized derivative compounds was found significant interactions with Albendazole with catalytic active site (CAS) of 1KZN. The predicted ADME properties revealed that all compounds fulfil drug-like criteria and could be considered as good candidate for drug development. All the synthesized compound derivatives have Standard Drug (Albendazole) like ADME properties.
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| Keyword:
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Benzimidazole derivatives, molecular docking simulation, 1KZN, Mcule, Insilco ADME, catalytic active site (CAS).
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.03.219
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| Download:
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