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Recent progress on synthetic coumarin scaffolds as anti-cancer agents in medicinal chemistry
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| Author:
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SIVAKUMAR KULLAMPALAYAM KRISHNASAMY, SURESHKUMAR KRISHNAN, KARTHIKEYAN LAKSHMANAN, MANIMEGALAI GOVINDHARAJ, ASHWIN PRIYA MANIKANDAN
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| Abstract:
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Cancer being the second leading cause of death in global scenario, there is dire need for new anticancer agents to overcome cancer. Newly developed anticancer agents should be void of cancer cell drug resistance, adverse effects and long-term therapy. In this context, pharmaceutical researchers have identified many coumarin derivatives either natural or synthetic scaffold and focused on modification of the active coumarin structures to improve therapeutic activity without cancer cell drug resistance and reduced toxicity. In this review the past 06 years anticancer researches from well-known and good impact journals are curated and analyzed. From this pool of articles, the compounds are classified based on the position and nature of substituent’s in coumarin nucleus and identified the important position for certain type of cancers. This review report helps in designing compounds that are best suited for the specific type of cancers.
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| Keyword:
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Coumarin, Anti-cancer, anti-tumor & Cancer Cell-lines
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.03.197
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| Download:
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