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Formulation and evaluation of enteric coated tablet of eluxadoline for the treatment of irritable bowel syndrome
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| Author:
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DHERE MANISHA, MAJUMDAR ARTI, MALVIYA NEELESH
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| Abstract:
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The purpose of this research work is to formulate enteric coated tablet of eluxadoline for the treatment the irritable bowel syndrome among the aim to increase solubility, oral bioavailability and to achieve target action of drug. Solubility of drug enhanced by the solid dispersion and prepared solid dispersion were evaluated by solubility study, Infra-red spectroscopy, X-Ray diffraction, drug content analysis and in-vitro drug release and further used in the formulation of enteric coated tablet to achieve target action of drug. Eudragit S 100 was used for the enteric coat to tablet. In a total of five batches of formulation from F1 to F5 were prepared via varying concentration of sodium starch glycolate and starch. On the basis of results of evaluation studies revealed that formulation F2 found to be most optimized formulation in terms of good flow properties, hardness, drug content, disintegration time. The enteric coating solution optimized by using Box Behnken design expert software 7.1.6. Optimized formulation exhibited greatest coating character and remained intact for 120 min in 0.1 M HCl and released maximum amount of the drug within the 60 min in phosphate buffer pH 6.8. Studies reveled those coated tablets can be used effectively to target drug delivery.
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| Keyword:
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Hydrotropic solid dispersion, Eluxadoline, Sodium caprylate, Eudragit S 100, In-vitro drug release.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.03.233
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| Download:
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