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Effect of AT1 Receptor Blocker on Urinary Water Reabsorption and Expression of Aquaporins.
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| Author:
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DR.PRASANNA PRADHAN, DR.JASMIN PANDA, DR.SOVAN PATTANAIK
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| Abstract:
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To evaluate the effect of angiotensin- 2 (AT1) receptor blocker on urinary water reabsorption and expression of aquaporins. 36 Male Wister rats were chosen and treated with a salt-restricted diet, vasopressin and vasopressin/losartan combination followed by assessment of 24-hour urine and plasma samples after 7 days of treatment, for evaluation of volume, osmolality, sodium, potassium, free water clearance, AQP excretion in cortex and medulla. Results were analyzed by using statistical software SPSS V.19.Rats who received combined vasopressin and losartan therapy revealed that there is an increased urine volume and decreased urine osmolality. Losartan and vasopressin combination also decreased solute free water re-absorption and decreases expression of aquaporins. Furthermore, the expressions of aquaporins are decreased in combination therapy as compared to vasopressin alone. The present study supports the interaction between angiotensin and vasopressin in the inner medullary collecting duct and influences the expression of aquaporins. The new therapeutic options can be exercised with the present knowledge of such molecular interactions. In the present study, we also found there is free water excretion and less sodium excretion. Aquaretic like vaptans are usually having many adverse effects but overall losartan has a proven efficacy and safety profile which can be used as an aquaretic in various clinical conditions like CHF(congestive heart failure) and SIADH(Syndrome of inappropriate antidiuretic hormone) with a proper dose optimization.
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| Keyword:
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Angiotensin-2, losartan, vasopressin, kidney, water re-absorption, Aquaporins.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.03.213
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| Download:
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