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Dermatological Adverse Reactions Due to Mefenamic Acid and Ciprofloxacin
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| Author:
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UPLOADED BY-ADMIN, SRINIVASA RAO, K G. P. MOHANTA, P. K. MANNA, THOTA PRASAD, RAGHU KUMAR V
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| Abstract:
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Adverse drug reactions are regarded as an important public health problem as they may be potentially life-threatening. The
World Health Organization defines Adverse drug reaction (Adverse Drug Reaction) as a response to a drug which is
noxious, unintended, which occurs at doses normally used in human for prophylaxis or diagnosis of a disease or for
modification of physiological function. We report two adverse drug reaction case reports. Firstly, an eight year old Indian
male child developed lesions on both palms on second day. Patient was prescribed Syrup Meftal (Mefanamic acid), Tablet
Paracetamol 250 mg and syrup Benadryl (Diphenhydramine hydrochloride, sodium citrate, ammonium chloride, menthol,
ethanol,). Patents had been treated with topical silver sulfadiazine, oral corticosteroids and antibacterial. Secondly, a 56-
year-old male patient had been treated with ciprofloxacin for gram-negative bacterial infection of the hands. Approximately
30 minutes after the first dose of ciprofloxacin, he developed generalized urticaria. Patient had been treated with, oral
corticosteroids and Cetirizine. The cases were identified during ward round participation along with clinicians. The causality
assessment was made using Naranjo’s algorithm. Finally, Clinicians are alerted that both Mefanamic acid and Ciprofloxacin
has the potential to cause severe Dermatological reactions and the necessity of being alert during therapy for promoting safe
use of medication.
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| Keyword:
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Pharmacovigilance; Adverse drug reaction; Mefanamic acid; Ciprofloxacin
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| DOI:
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