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Experimental Investigation On Multiparticulate System For Antidepressant Drug
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| Author:
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MR.FOLITARTHA ROY, SAPNA SHARMA, MS.ARCHANA SAHU, MR.PRABHAT KUMAR
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| Abstract:
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When diclofenac sodium was used as a model pharmaceutical, DR multi particles were produced and processed into solid oral dose forms such as capsules and tablets. Particles from many sources, including microcrystalline cellulose, sugar spheres, malt, and a brand new kind of calcium phosphate pellet (inert core), were utilised in the development of multiple unit pellet systems (MUPS). Both the mechanical and dissolving qualities of drug-loaded pellets were impacted by the inert cores' material composition. Using a physic-grad device and a non-relevant dissolution method, we were able to thoroughly test our formulations in a pH-simulated gastrointestinal environment. For the first time, our technique revealed considerable disparities in the formulations' sensitivity to hydrodynamic conditions.
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| Keyword:
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Calcium phosphate-based pellets, Multiple unit pellets systems, Diclofenac sodium Starter pellets physic-gra.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.02.439
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| Download:
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Request For Article
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