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Formulation Development and Evaluation of Sustained Release Matrix Tablet by Liquisolid Technique
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UPLOADED BY-ADMIN, IRSHAD AHMAD, CHETAN DEORE, MILIND UMEKAR, MINAL NEEL, SWEETY BANKAR
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| Abstract:
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It is suggested that Liquisolid technique has the potential to be optimized for the reduction of drug dissolution rate and here
by production of sustained release systems. In the present study Losartan potassium was dispersed in Polysorbate 80 as the
liquid vehicle. Then a binary mixture of carrier-coating materials (Eudragit RS or RL as the carrier and Silica as the coating
material) was added to the liquid medication under the continuous mixing in a mortor. The final mixture was compressed
using the manual tableting machine. The effect of drug concentration and loading factor on release profile of Losartan
potassium from Liquisolid compact were investigated at two pH values (1.2 and 6.8). The release rate of Losartan potassium
from Liquisolid compact was compared to the release of Losartan potassium from conventional tablets. Fourier transform
infrared spectroscopy, X-Ray Crystallography and Differential Scanning Calorimetry were used to investigate the formation
of any complex between drug and excipients or any crystallinity changes during the manufacturing process. Losartan
potassium tablets prepared by Liquisolid technique showed greater retardation properties in comparison with conventional
matrix tablets. This investigation provided evidence that Polysorbate 80 has important role in sustaining the release of drug
from liquisolid matrices, and reduction of glass transition temperature of the polymer can be the reason for the release
prolongation of liquisolid tablets. The kinetics studies revealed that most of the liquisolid formulations followed Korsmeyer-
Peppas eq., which states that the release of drug might follow the mixed kinetics.
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Liquisolid Technique, Loading Factor, Sustained Release, Losartan potassium.
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| DOI:
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