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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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A Study On The Evaluation Of Antioxidant, Lipid Peroxidation And Toxic Effects After Apple Intake In Healthy Human Volunteers

Author: FAIZAL.P , B.SATHEESAN, K.T AUGUSTI
Abstract: A study was undertaken for evaluating the antioxidant, antiperoxidative and toxicity effects if any after administration of the fruit apple. A total number of 40 healthy human volunteers (age group of 20 – 40Yrs) were selected for the study. They were divided into three groups as Group Ia – Healthy human volunteers before apple intake, Group Ib – Healthy Human volunteers after 45 days of apple intake and Group Ic – Healthy human volunteers after 90 days of apple intake. Participants suffering from any diseases/disorders that may interfere with the study were excluded. 5mL of blood sample was taken for the analysis. Blood samples were collected before the intake, 45 days after the intake and 90 days after the intake of fresh apple fruit at a dosage of 200g/day. Serum/Plasma was separated and estimated using the standard methods. Our results indicated that both 45 and 90 days supplementation of apple increased the antioxidant status and has shown decreased antiperoxidative effects without any observable toxicity. The increase in antioxidant status and decrease in peroxidation effects were more significant after intake of apple for a period of 90 days. The overall findings indicated that the intake of apple is efficient in enhancing the body's antioxidant status and decreasing the peroxidative effects without any observable toxicity.
Keyword: Free radicals, Antioxidants, Antiperoxidative, Antitoxic
DOI: https://doi.org/10.31838/ijpr/2022.14.01.010
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