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Anti-Inflammatory And Wound Healing Effects of Grewia Umbellata Roxb.
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| Author:
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PRASANNA HABBU, SMITA MADAGUNDI, VAISHALI TODKAR
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| Abstract:
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Wounds are inescapable events of life, arising due to physical, chemical injury or microbial infections. Traditional medical practitioners residing in the vicinity of the forests use Grewia Umbellata as hemostatic and wound healing plant. Hence, the present study aims scientific validation of the plant for wound healing and anti-inflammatory activity. Aqueous (GUAE) and ethanolic (GUEE) extracts were prepared, evaluated for acute and dermatological toxicity study. Wound healing potential of 5% GUAE and GUEE was investigated in excision and incision models in rats. Anti-inflammatory activity of GUAE and GUEE at the doses of 200 & 400 mg/kg was carried out in carrageenan induced hind paw edema model. The percentage wound closure for GUEE and GUAE ointments was found to be 99.76% and 93.70% respectively on 15th day and found to be significant (P<0.001) as compared to control and ointment base treated group. This is also supported by decrease in the period for epithelialization (P<0.001). Tensile strength of animals applied with GUEE and GUAE ointments were significantly increased as compared to control group. Hydroxyproline content was found to be elevated in GUEE and GUAE treated groups compared to control group of animals. GUEE (400 mg/kg) body weight showed maximum inhibition (61.97%) of hind paws edema during first hour showing significance (P< 0.001) as compared to control group. GUEE and GUAE exhibited potential wound healing and dose dependent anti-inflammatory activity in rodent models. This may be due to the presence of flavonoids, tannins, triterpenoid which is yet to be explored.
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| Keyword:
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Grewia Umbellata, Grewia heterotricha, wound healing, anti-inflammatory
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2022.14.03.009
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| Download:
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