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Formulation Design, Development And Invitro Evaluation Of Mouth Dissolving Tablets Of Eletriptan
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| Author:
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N.POOJITHA , DR.V.ANJANEYULU, DR.VIJAY KUMAR GAMPA
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| Abstract:
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The main objective of this research work was to formulate and evaluate the orodispersible tablets of eletriptan hydrobromide (EH). EH is a selective 5HT1B/1D receptor agonist used in the treatment of migraine. Formulation of EH in the form of orodispersible tablets (ODT) would facilitates the release of the drug in less time; hence it can be used in acute treatment of migraine. The EH-ODT formulations were prepared with varying concentrations of different supradisintegrants such as crosspovidone, croscarmellose sodium, and sodium starch glycolate by direct compression method. Prepared EH-ODTs were evaluated for physical parameters, drug content, disintegration time, and in vitro drug release. Other parameters such as wetting time, water absorption ratio, and drug-excipient compatibility were also evaluated. Based on the results, formulation F9 was selected as optimized formulation with disintegration time of 18 sec and cumulative percentage drug release of more than 95% in 10 min. The optimized formulations were subjected to short term stability study by storing the formulations at 40± 2ºc/75± 5% RH up to three months. The formulations F9 was found to be stable during the study. Therefore, the results confirm the ODTs of EH could be considered as an alternative for acute treatment of migraine.
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| Keyword:
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Orodispersible tablets, Eletriptan hydrobromide, Migraine, direct compression, disintegration time.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2023.15.01.003
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| Download:
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