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Ocular Novel Formulations:Current Impact and Future Challenges
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| Author:
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TANUJA LUITEL SHARMA, ANJALI BASNETT, DEEPSHIKA PRADHAN, SRIJITA CHAKRABARTI
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| Abstract:
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Human eyes, the most sensitive and vital organ of human body, comprise of various ocular barriers that makes it very challenging for the formulating scientist to develop and design ophthalmic dosage forms. There are several conventional ophthalmic dosage forms available in the market however; they possess some limitations such as rapid drainage, less bioavailability, low corneal permeation and non-targeted delivery which leads to ocular toxicity. Therefore, there is a need for novel ocular formulations that aim at delivering the ocular dosage forms to targeted ocular tissues to improve therapeutic drug level and prolong the duration of action of drugs into targeted tissue causing no adverse effects. The novel delivery systems delay the elimination of active ingredient from eyes and also improve corneal penetration of drug molecules. Novel ocular formulations have many advantages with a few demerits that need to be overcome. The fruitful results of the current researches based on novel ocular drug delivery system can pave the way for the substitution of conventional dosage forms with novel formulations in the field of ophthalmic drug delivery system in the coming years. In this paper, emphasis have been given to the various approaches of novel ocular drug delivery system comprising of liposomes, in-situ gels, nanoemulsion, niosomes and dendrimers which can be promising delivery system for ophthalmic dosage forms.This review paper also enumerates the findings of various experimental data regarding the novel ocular dosage forms
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| Keyword:
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Dendrimers, in-situ gels, liposomes, nanoemulsion, niosomes, novel ocular drug delivery system
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2023.15.02.005
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| Download:
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