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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Real Time Long-Term Stability Assay Of Ointment Of Snakehead Fish Extract (Channa striata) and Golden Sea Cucumber Extract (Stichopushermanii) Using Humectant Agent Variations

Author: MOHAMAD ANDRIE, WINTARI TAURINA
Abstract: One of the natural ingredients that have the potential to accelerate wound healing is snakehead fish. Researchers opt to add a stabilizer in the form of a humectant agent to increase stability through long-term stability tests (real-time). Thus, it encourages researchers to optimize the humectant agent, determine the ointment in long-term stability tests, to produce a stable herbal-based ointment product with the nutritional content of the fish extract. This study aims to determine the shelf life of the ointment with the best formula composition for the product from snakehead fish extract with a humectant agent as a wound-healing drug product that is effective, safe, and comfortable to use by the public. Based on the physical stability test of the snakehead fish extract ointment at the 0th, 1st, and 3rd months with the intermediate stability test method carried out at a temperature of 30° ± 2°C/ RH 65% ± 5%, the resulting ointment was brownish green and had a distinctive smell of cloves and betel nut. All ointment preparations have good homogeneity, adhesion, and spreadability and meet the test requirements for good ointment preparations. The results of statistical analysis of all formulas until the 3rd-month test showed that the results of the paired sample T-test on all formulas showed a significant difference in pH values. Based on the results of the chemical stability test, an increase and decrease in protein content in the preparation were obtained during storage.
Keyword: Snakehead fish extract, Channa striata, ointment, humectant, stability
DOI: https://doi.org/10.31838/ijpr/2023.15.04.001
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