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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Constipation As An Adverse Effect Of Clopidogrel: A Case Series

Author: SUMAIYA SALEEM, PURUSHOTHAMA REDDY K, PADMALATHA KANTAMANENI
Abstract: Clopidogrel is an antiplatelet drug that is mostly used in patients with acute coronary syndrome and ischemic conditions of the body. It is a thienopyridine derivative that acts mainly by binding specifically and irreversibly to the platelet P2RY12 purinergic receptor. It inhibits ADP-mediated platelet activation and aggregation. Like other antiplatelet drugs, clopidogrel also exhibits hematological and non-hematological adverse effects, gastrointestinal effects being the most common among them. Though rare, constipation is one of the adverse effects of clopidogrel. Its incidence and mechanism are unknown, but few studies suggest that it may be possible since clopidogrel influences gastrointestinal motility and secretomotor function by P2Y12R blockage. This case series aims to explore and document cases of constipation as an adverse effect of clopidogrel use. Three case reports have been presented that show constipation as a potential adverse effect of clopidogrel. The study concludes that the use of clopidogrel in patients with coronary artery disease may be associated with constipation and that it may be better to use Ticagrelor in such patients. Further controlled trials and confirmatory studies are required to understand better the occurrence and causal association between clopidogrel and constipation.
Keyword: Case Series, Clopidogrel, Constipation, Adverse Drug Reaction, Gastrointestinal effects, Ticagrelor, Coronary Artery Disease.
DOI: https://doi.org/10.31838/ijpr/2023.15.04.005
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