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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Compatibility Study of Ranitidine with Pharmaceutical Excipients

Author: NEHA RAUT, HARSHAL M. BALPANDE, CHETAN N DEORE, MILIND J UMEKAR, NANDKISHOR R KOTAGALE
Abstract: Binary mixtures (1:1) of ranitidine with variety of pharmaceutical excipients stored for 3 months at 50 ± 20C, 25 ± 30C, 2 - 80C, 40 ± 20C/75 ± 5% RH were observed for the physical changes, moisture gain and analyzed by UV spectrophotometer to investigate the compatibility of selected excipients with ranitidine. Set of observations revealed RNH interaction with butylated hydroxyanisole, polyvinyl pyrrolidone, hydroxy propyl methyl cellulose, microcrystalline cellulose and magnesium stearate at all the storage conditions. Physicochemical characterization of stored binary mixtures by differential thermal analysis and differential scanning calorimetry divulged that RNH was obviously incompatible with butylated hydroxyanisole, polyvinyl pyrrolidone, hydroxy propyl methyl cellulose, microcrystalline cellulose and magnesium stearate. Further, altered infrared spectra indicated the possibility of molecular changes in Ranitidine-excipient mixtures. Analytical profiles of the mixtures were an evidence of interactions leads to incompatibility.
Keyword: Compatibility, Ranitidine, Excipients, Butylatedhydroxyanisole, Polyvinylpyrrolidone, Hydroxypropylmethylcellulose, Microcrystallinecellulose, Magnesiumstearate
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