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Formulation and Development of Polyherbal Gel of Alhagi camelorum, Scaphium affine, Barringtonia acutangula for Treatment of Skin Disease
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| Author:
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SUNIL KUMAR SHAH, MUKESH KUMAR PATEL, ANUJ KASATI, SHALINI SINGH
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| Abstract:
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Three medicinal plants with strong antibacterial potential - Alhagi camelorum, Scaphium affine, Barringtonia acutangula were chosen for this study's formulation of a polyherbal gel to treat skin disease. Plant material was collected, subjected to extraction with proper solvents. Further qualitative & quantitative study was performed along with formulation and evaluation of polyherbal gel. The percentage yield of Alhagi camelorum, Scaphium affine and Barringtonia acutangula were found 5.5%, 9.4% and 7.3% respectively. The phytochemical screening of the extract revealed the presence of several bioactive in all the three plants. Total phenol content was found to be 0.854 mg/100mg and 0.796 mg/100mg and 0.847 mg/100mg in Alhagi camelorum, Scaphium affine and Barringtonia acutangula respectively. Further about six formulations of gel were created all of them has clear colour, no clogging, good homogeneity and smooth texture. The spreadibility ranged from 13.8±1 gcm/sec to 24.6±1 gcm/sec. The pH of gel varied from 7.05±0.24 to 7.80±0.20. The viscocity ranged from 2096±27 to 3048±14. The maximum phenol content was found to be associated with PHG5 formulation which is 86.6±0.5 %. In case of Klebsiella pneumoniae the zone of inhibition was found to be 12±0.5, 14±0.74 and 18±0.57mm respectively for concentration of 0.125mg/ml, 0.25 mg/ml and 0.5mg/ml. In case of Bacillus subtilis the zone of inhibition was found to be 10±0.74mm, 13±0.94mm &16±0.86mm respectively. The In-vitro drug release study of polyherbal gel (PHG5) revealed that about 98.95% drug get released in 120min. Thus it can be concluded that formulated polyherbal gel can be used in first line treatment.
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| Keyword:
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Skin disease, Polyherbal gel, Alhagi camelorum, Scaphium affine, Barringtonia acutangula
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2025.17.03.013
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| Download:
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