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Formulation and evaluation of transdermal patches of glibenclamide
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UPLOADED BY-ADMIN, MANISH P PATEL, M M PATEL, K N PATEL, D R PATEL, U L PATEL
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| Abstract:
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Glibenclamide, a hypoglycemic agent belonging to sulphonyl urea class. Sulphonyl urea
causes hypoglycemia by stimulating insulin release from pancreas beta cells. Sulphonyl urea also
may further increased insulin level by reducing hepatic clearance of the hormone. An attempt has
been made to formulate transdermal patches using Eudragit RL 100, Eudragit RS 100, Polyvinyl
pyrollidone ( PVP) as polymers, glycerol and propylene glycol as a plasticizers and Span 80 as a
permeation enhancer by solvent casting method with aim of to study the release kinetics of drug
with a view to reduce the dose frequency, improving patient compliance, greater therapeutic
efficacy and to prevent its first pass metabolism to achieve a controlled drug release and
overcome some draw backs such as gastric disturbance, hepato toxicity with improved
bioavailability. The prepared transdermal patches were then evaluated for uniformity of
thickness, weight variation, hardness, surface pH, tensile strength, swelling index (%), folding
endurance, water vapor permeability, drug content. In vitro drug release studies of formulated
patches were performed by studying the diffusion through human cadaver skin. The IR analysis
of the sample was carried out for qualitative compound identification using KBr disc method.
Out of eight formulations prepared, the formulation containing Eudragit RL 100 with propylene
glycol as plasticizer showed complete and prolonged release with 98.02 % at the end of 24 hours.
The data from the In vitro release was fitted to various kinetic models like zero order, first order,
and Higuchi equations to determine the kinetics of drug release.
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| Keyword:
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Glibenclamide, transdermal patches, Eudragit RS100, Eudragit RL100, glycerol,Propylene glycol, In vitro release
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| DOI:
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