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Proniosomes: Recent Advancement In Novel Drug Delivery
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UPLOADED BY-ADMIN, RACHIYATA DUBEY, AMIT SINGH,, GARAUV K. SARAOGI, AKHILESH K. SINGHAI
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| Abstract:
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Several novel drug delivery systems have come into sight encircling various routes of administration to accomplish
controlled and targeted drug delivery. Encapsulation of the drug in vesicular structures is one such system, which can be
envisaged to extend the existence of the drug in systemic circulation and decrease the toxicity. Vesicular systems especially
niosomes and liposomes are well recognized significant system for the transdermal route but the unstable nature of these
carriers are the major dilemma in the development of vesicular system. New promising concept of provesicular system
endows with the solution to get rid of the stability concern as well as provides an edge of higher entrapment efficiency over
conventional systems. Proniosomes are water soluble carrier particles that are coated with surfactant and can be hydrated to
form niosomal dispersion immediately before use on brief agitation in hot aqueous media. Hence, enhanced delivery of
bioactive molecules through skin by proniosomal carrier opens new challenges and prospects for the expansion of novel
improved therapies.
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| Keyword:
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Proniosomes, vesicular system, niosome, transdermal delivery
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