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Improvement the aqueous solubility of the prenylated coumarins using cyclodextrin complexation
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| Author:
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BIZHAN MALAEKEH-NIKOUEI, TALIE ESFAHANIZADEH2, EHSAN JALILI-JAMSHIDIAN2, MOHAMMAD YAHYA HANAFI-BOJD2, BIZHAN MALAEKEH-NIKOUEI3
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| Abstract:
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Umbelliprenin and auraptene are natural coumarin compounds extracted from different plants of Apiaceae family especially the Ferula species. Up to now, significant biological activities of these substances have been reported including anti-inflammatory, and tumor preventive effects. Low solubility in water limits their usage in in vitro and in vivo studies. To enhance aqueous solubility of umbelliprenin and auraptene, we used a method of complexation with cyclodextrins (CDs). In the solubility enhancement studies, 6 types of CDs called a-, ?-, ?-, HP-?-, HP-?- and SBE-?-CD together with 2 different mixtures, a+HP-? or HP-?+HP-?, were used in 4 concentrations (5, 10, 15 and 20 % w/v). Mixture of HP-?- and HP-?-CD in concentration of 20% had the most effect on solubility enhancement of umbelliprenin while in case of auraptene, HP-?-CD (concentration of 15%), SBE-?-CD (concentration of 10%) and mixture of HP-?- and HP-?-CD (concentration of 20%) showed the best effect on aqueous solubility. The results of this study showed that CDs significantly increased the aqueous solubility of umbelliprenin and auraptene.
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| Keyword:
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Aqueous solubility, Auraptene, Cyclodextrins, Umbelliprenin
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