*Five Years Citation in Google scholar (2016 - 2020) is. 1451*   *    IJPR IS INDEXED IN ELSEVIER EMBASE & EBSCO *       

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
No Data found.
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Development of Poly-herbal Tablets for Colon Targeting Using Natural Polymer

Author: VEDHA HARI B.N, RAJALAKSHMI G, KANCHALOCHANAA SN, JOSHNY JOSEPH, , VEDHA HARI BN, , RAMYA DEVI D
Abstract: Triphala churna contains Haritaki, Bibhitaki and Amalaki in combination of 1 part each. It is indicated for its astringent, laxative and anti-bacterial activity, administered at doses of 1-3 gm with hot water or honey. The present work involves the formulation of Triphala churna as tablets by wet granulation method, to increase the stability as single unit dosage form and to mask the bitter taste of the powder. Tamarind seed polysaccharide (TSP) isolated from the kernel of tamarind seeds is used as the binder for the tablet formulation since it is degraded by the enzymes present in the colon region, so that the drug release is more in the lower part of the intestine, which is the site for increased absorption and its pharmacological action. The formulation is optimized by changing the concentration of TSP binder as the variable. The powder and granules are evaluated for pre-formulation parameters and optimized for tablet compression with required hardness. The addition of TSP in tablets show good disintegration in alkaline media with enzymes and ensure complete release of the drug. The microbial load and XRF studies performed for the optimized batch of tablets prove the formulation’s sterility, stability and standard limits of metal ions concentration.
Keyword: Triphala churna, Wet granulation, X-Ray Fluorescence spectroscopy, Microbial load
Download: Request For Article
 
Clients

Clients

Clients

Clients

Clients
ONLINE SUBMISSION
USER LOGIN
Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free