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Innovative and Rational Delivery of Rizatriptan Benzoate by Formulating Nasal Microparticles
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| Author:
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DHIREN SHAH, SHANTU PATEL
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| Abstract:
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The present study has been undertaken with the objectives to prepare spray dried mucoadhesive microparticles of the antimigrain drug, rizatriptan using natural polymer (chitosan) for nasal administration. Various ratios of drug and chitosan were prepared and spray dried with spray dryer which produced the microparticles having average particle size of 19 µ. The prepared microparticles were studied for the ex-vivo mucoadhesion and the value found to be more than 180 minutes. The swelling property of the microparticles was studied and the swelling index was found in the range of 0.68 to 1.19. The entrapment efficiency was determined by UV spectrophotometry and found between 90.12 – 99.67 %. All the formulation shows the time require to reach maximum concentration of drug in dissolution medium (Tmax) in the range of 60 to 90 minutes. The microparticles are also characterized by Powder X-ray Diffraction and Differential scanning calorimetry analysis. Spray drying is a suitable technique for formulating microparticles of rizatriptan and nasal mucoadhesion effect attributed to chitosan polymer. The nasal administration device for prepared microparticles was successfully developed by the modification of the Rotahaler® device.
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| Keyword:
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Nasal drug delivery system, Rizatriptan benzoate, Chitosan, Spray drying, Rotahaler®
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| EOI:
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| DOI:
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