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Nephroprotective Effect of Gossypium Herbaceum Linn. on Gentamicin Induced Renal Injury
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| Author:
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PREETI BOMMANNAVAR, KALPANA S PATIL
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| Abstract:
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ABSTRACT
Gentamicin is an extensively used aminoglycoside antibiotic and has been reported to produce nephrotoxicity even at therapeutic dose level. Therefore, the work was undertaken to carry out the nephroprotective activity of Gossypium herbaceum Linn. The nephroprotective activity on alcoholic and aqueous root extracts of Gossypium herbaceum Linn was carried out by inducing nephrotoxicity in rats by administered gentamicin intraperitoneal at a dose of 40mg/kg body weight twice a day for 7 days. Both alcoholic and aqueous extract at the dose of 250 and 500 mg/kg body weight showed significant nephroprotective activity in gentamicin induced nephrotoxicity model as evident by increase in urine output, with decrease in elevated serum creatinine and serum urea which was further confirmed by histopathological study and body weight gain. Gentamicin induced glomerular congestion, blood vessel congestion, epithelial desquamation, accumulation of inflammatory cells and necrosis of the kidney cells were found to be ameliorated in the groups receiving the root extracts of Gossypium herbaceum Linn. at both dose 250 and 500 mg/kg body weight. Data revealed that the aqueous extract of Gossypium herbaceum Linn. significantly (P<0.01) prevents renal damage by normalizing increased levels of renal markers. From the present study, it may conclude that alcoholic and aqueous extracts of Gossypium herbaceum Linn. possess potential nephroprotective activity.
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Gossypium herbaceum, Gentamicin, kidney function tests, Nephrotoxicity Activity, Nephron
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