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Formulation and Evaluation of Ketoprofen Loaded Transdermal Drug Delivery.
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| Author:
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UPLOADED BY-ADMIN, SOMASHEKHARA C.N, K.GOWTHAMARAJAN, D.V.GOWDA, RAJESH. N, SIDDARAMAIAH
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| Abstract:
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The potential applications of highly biocompatible of Transdermal drug delivery system
(TDDS) as a tropical drug carrier system for the percutaneous delivery of Ketoprofen. TDDS
films were prepared by using Hydroxy Propyl Methyl Cellulose(HPMC) and Polyethylene
glycol 400 (PEG-400) by varying the blend ratios viz., 10:0, 8:2, 6:4, 4:6 and 2:8 (w/w %).
The drug loaded membranes were evaluated for thickness, tensile behaviors, content uniformity,
in-vitro drug release studies and skin irritation test effect. Dimethyl sulfoxide (DMSO)
was used to evaluate the percutanious enhancing effect. Ketoprofen was found to be compatible
and stable with the prepared formulation as confirmed by Fourier transform infrared
(FTIR) and Differential Scanning Calorimetry (DSC), studies. In-vitro release studies
showed a controlled release for 8h. Skin irritation test reveals no signs of erythema, edema
or ulceration. From the present study it can be concluded that, the prepared transdermal films
can be used to achieve controlled release of the drug and showed good skin tolerability.
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| Keyword:
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Ketoprofen, HPMC, Dimethyl sulfoxide, Transdermal drug delivery.
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| EOI:
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| DOI:
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