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Influence of Ethylcellulose on Dissolution Profile of Carbamazepine Cyclodextrin Complex
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| Author:
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GHANSHYAM PARMAR, GANDHI K S, SAILOR G U, CHAUHAN S P, SETH A K
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| Abstract:
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Carbamazepine (CBZ), a BCS class II drugs used in treatment of trigeminal neuralgia.The present study was carried out to prepare and characterize extended-release matrix tablets of CBZ using ethylcellulose (EC) as a polymer and drug was solubilized by manufacturing inclusion complex with ?-cyclodextrin (?-CD). First, inclusion complex were prepared with ?-CD and then, tablet were prepared with EC. The tablet were formulated by keeping the 1:3 drug: ?-CD ratio constant but varying drug: polymer ratio (1:1, 1:1.5, 1:2, 1:2.5, 1:3, 1:3.5).The in-vitro drug release study revealed that either EC preparation was able to extend the drug release only for 24 hours. The CBZ: ?-CD complex improve the solubility and thus improve the dissolution profile of CBZ.These results suggested that the tablet formulated using EC as a drug retarding polymers could be advantageous than conventional CBZ tablets.
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| Keyword:
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Extended Release; Carbamazapine; ?-cyclodextrin; Ethyl cellulose; Inclusion complex
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| EOI:
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| DOI:
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-
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| Download:
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