*Five Years Citation in Google scholar (2016 - 2020) is. 1451*   *    IJPR IS INDEXED IN ELSEVIER EMBASE & EBSCO *       

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Synthesis and Biological Activity of Some Quinolino Pyrazole Derivatives

Author: SHILPI SONKER, DR.DEVENDERPATHAK
Abstract: A new series of pyrazole based quinoline were synthesized and evaluated for antimalarial and antibacterial activity. The rationale behind the synthesis of new series of quinolino pyrazoles (4a-4e) and (4a’-4e’) is in order to discover a new molecule which leads to dual anti-malarial–antimicrobial agents. The synthesized novel compounds were screened for their anti-malarial activity using Vero cell line (C1008; Monkey kidney fibroblast) against Plasmodium falciparum (3D7 strain) with the Chloroquine diphosphate and SI was measured by using IC50 and CC50 of compound. The results revealed that compounds 4c, 4e, 4a’ and 4e’ showed higher efficacies and potencies for anti-malarial activity comparable to the reference standard Chloroquine diphosphate. Additionally, the synthesized compounds were evaluated for their in vitro antimicrobial activity against two gram positive, gram negative and antifungal strain. Four compounds 4c, 4e, 4a’ and 4d’showed considerable broad spectrum activity against all the tested Gram-positive and Gram-negative bacterial strains as well as displayed significant antifungal activity.
Keyword: Chalcones, Pyrazoles, Sulfonamides, Plasmodium falciparum, Antimalarial activity, Antimicrobial activity, SYBR Green-I (Invitrogen)
Download: Request For Article
 




ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free