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EFFECT OF PARTICLE SIZE ON DISSOLUTION PROFILE OF CIPROFLOXACIN HYDROCHLORIDE FROM FLOATING MATRIX TABLET
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DIPANJAN GHOSH, DEBABRATA GHOSH DASTIDAR, RITAM BAIRAGI, SWATI ABAT, ARINDAM CHATTERJEE
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| Abstract:
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Ciprofloxacin hydrochloride is a good candidate drug for gastro retentive drug delivery system (GRDDS). Floating tablet
of ciprofloxacin hydrochloride was prepared with wet granulation method using HPMC as matrix material and PVP-K30
as binder. The objective of this study was to find out the effect of granule size on the floating behavior and drug release
profile. Tablets were prepared with granules of different particle size (over size to mesh no. 22, 22/44, 44/60, 60/85,
85/120, and under size to mesh no. 120). It was found that tablets prepared with finer granules float quickly and
remained float for prolonged period of time. The erosion-controlled, zero order drug release mechanism was
independent of particle size of granules. But with decrease of granule size, dissolution efficiency was significantly
increased. Tablets prepared from granules of mesh no. 85/120 and granules that was undersize of mesh no. 120, were
similar with respect to drug dissolution profile, though the later released maximum percentage of drug (98±2%) and had
maximum dissolution efficiency of 47±2% in 8 h.
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| Keyword:
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Floating tablet, Wet granulation, DDSolver, similarity factor, difference factor, Ciprofloxacin hydrochloride Abbreviation :HPMC=Hydroxy-propyl methyl cellulose, PVP= Polyvinyl Pyrrolidone, GIT=Gastro-intestinal Tract, GRDDS= Gastro Retentive Drug Delivery System, FDDS= Floating Drug Delivery System
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| DOI:
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