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A Novel Alternative to Ocular Drug Delivery System: Hydrogel
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| Author:
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UPLOADED BY-ADMIN, DIVYESH SHASTRI, L. D. PATEL
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| Abstract:
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Sustained and Prolonged drug delivery approaches are very common in today’s Pharmaceutical formulation
design and research work is still going on in achieving better drug product. Ophthalmic use of
viscosity-enhancing agents, penetration enhancers, cyclodextrins, prodrug approaches, ocular inserts and
the ready existing drug carrier systems along with their application to ophthalmic drug delivery are very
common to improve ocular bioavailability. Amongst these hydrogel (insitu gel forming) systems are of
very important. They help to increase in precorneal residence time of drug to a sufficient extent that an
ocularly delivered drug can exhibit its maximum biological action. The concept of this innovative ophthalmic
delivery approach is to decrease the systemic side effects and to create a more pronounced effect
with lower doses of the drug. Many polymers are very useful with majority of hydrogels, which undergo
reversible sol-gel phase transitions in the ocular cul-de-sac to form viscoelastic gels due to phase changes
of polymers in response to the physiological environment (temperature, pH and presence of ions in organism
fluids. These insitu forming gels can be applied as solution and exhibit pseudo plastic behavior to
minimize interference with blinking, increase precorneal residence of the delivery system and enhanced
ocular bioavailability. Now a days insitu gels have been used as vehicles for the delivery of drugs for both
local treatment and systemic effects. Different administration routes other than ocular have been explored,
including for example, cutaneous and subcutaneous delivery, dental, buccal delivery and delivery to the
esophagus, stomach, colon, rectum and vagina.
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| Keyword:
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Ocular drug delivery, Environment sensitive, Preformed, Insitu, Hydrogel.
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| EOI:
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| DOI:
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