IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
COMPARISON OF SAFETY REPORTS: HIGH-RISK VERSUS LOW-RISK PATIENTS

Author: JUNY SEBASTIAN, ALISHA BESTO, RINUSHAJI, , T VIJAYALAKSHMI, MELAMBHA SURONG, M RAMESH
Abstract: To determine the incidence, causality, severity, predictability, preventability, seriousness, predictors and direct cost associated with the management of ADRs in high-risk and low-risk patients. The prospective study enrolled eligible patients in to high-risk and low-risk categories as per the developed criteria. Required data were collected whenever there was an ADR detected among the study population. Data was analyzed for incidence, causality (by Naranjo’s scale and WHO scale), severity (by Modified Hartwig and Siegel scale), predictability, preventability (by Modified Shumock and Thornton scale), seriousness (by ICH-GCP guidelines) and direct cost associated with the management of ADRs. The incidence of ADRs in high-risk patients was 11.28% and that of low-risk patients was 10.44%. Majority (56.56%) of highrisk patients who developed ADRs were females while 69.01% of low-risk patients who experienced ADRs were males. Drugs most commonly implicated in ADRs among high-risk patients were insulin (8.94%) followed by tramadol (6.50%) whereas among low-risk patients, ceftriaxone (15.06%) and insulin (10.95%) were the drugs implicated. Majority of the reaction were ‘probable’ in their causality category in both high-risk (82.1%) and low-risk patients (82.19%). A total of 99% of ADRs were ‘not preventable’ in both high-risk and low-risk groups. The incidence of ADR was equal in both high –risk and the low-risk group and there was no change in the severity and preventability of the reported ADRs. Therefore, early detection and prevention of ADRs in any patients are essential to avoid adverse outcomes of ADRs.
Keyword: Adverse Drug Reactions, High-risk, Low-risk, Predictors of ADRs.
DOI: https://doi.org/10.31838/ijpr/2018.10.03.008
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free