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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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IN- VITRO AND IN-VIVO POTENTIAL OF ADENIUM OBESUM FLOWER EXTRACTS INDIABETIC CHALLANGED RAT MODEL

Author: SIREESHA KALVA1*, RAGHUNANDAN N
Abstract: Diabetes mellitus is one of the wide spread and severe metabolic disorder in humans all over the world. Various medicinal plants have effectively been used to conquer this health problem. Adenium obesumcommonly known as desert rose belongs to the family Apocyanacea. The present study was designed to evaluate the in-vivo and in-vitro antidiabetic potential of Adenium obesumflowers in streptozotocin induced diabetic rats.Diabetes was induced by giving streptozotocin intraperitoneally(35-50mg/kg). The methanolic(MEAO) and ehtyl acetate (EAEAO) extracts of Adenium obesumflowers were administered at a dose of 100,200,300 mg/kg each orally.The in-vitro alpha-amylase inhibitory activity of MEAO and EAEAO was done by spectrophotometric method.Acarbose was taken as a standard drug .The invivo anti-hyperglycemic activity was evaluated by estimation of blood glucose levels by glucose–oxidase method and serum insulin was estimated bychemiluminescence assay. Metformin was administered as standard drug at a dose of 50mg/kg.Boththe extracts of Adenium obesumflowers have shown a very strong alpha-amylase inhibitory activityin a dose dependent manner. Both the extracts administered at different doses have shown significant reduction in the bloodglucose levels (p<0.0001) when compared to the diabetic group. A significant increase in the serum insulin (p<0.0001) was also observed with both the extracts in diabetic groups. The results suggested that Adenium obesumflowers extracts may have potent anti-diabetic activity, justifying the use of the drug for the treatment of diabetes mellitus.
Keyword: Adenium obesum, Streptozotocin, Acarabose, Alpha-amylase.
DOI: https://doi.org/10.31838/ijpr/2018.10.03.010
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