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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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90-Days Repeated Dose Oral Toxicity Study on a Traditional Polyherbal Formulation Used in Urinary Disorders

Author: MOHAMMAD KHAN,, MOHD. UROOJ, SYED HASHIM RAZVI, SYED SHOEB AHMED, MUNAWWAR HUSAIN KAZMI, GULAM MOHAMMED HUSAIN*
Abstract: Majoon-e-Kundur (MK) is a compound Unani Pharmacopoeial formulation used in Taqteer-ul-Baul (Dribbling of urine), Salas-ul-Baul (Urinary incontinence), BaulFilfarash (Nocturnal enuresis), Surat-e-Inzal (Premature ejaculation) and Zof-e- Masana (Weakness of urinary bladder). Present study is designed to evaluate sub-chronic toxicity of MK in rats. Present study was carried out to evaluate 90 days repeated dose oral toxicity of MK in rats.Study was carried out on SD rats of both sexes. Animals were divided into three groups (n=10 per sex per group). MK was administered at the dose of 1028 and 2000 mg/kgbw/day p.o. for 90 days. Control animals were administered with vehicle. After completion of 90- days, blood samples were collected for haematological and biochemical analysis and animals were sacrificed, organs were harvested for weight determination and histopathological evaluation. Animals in MK-treated groups did not reveal any abnormal behaviour or clinical signs indicative of systemic toxicity. There was no toxicologically significant alteration observed in body weight, feed intake, haematological and biochemical parameters, and relative organ weights of control and MK treated rats of either sex.No toxicologically significant effects were observed with respect to clinical signs of toxicity, haematology, clinical chemistry, organ weight and gross necropsy findings in MK treated rats at 1028 and 2000 mg/kg bw or in control animals. The histopathological finding did not reveal any toxicologically significant change. Thus, the No Observed Adverse Effect Level (NOAEL) of MK may be considered >2000 mg/kg bw in rats.
Keyword: Toxicity, Herbal, Majoon-e-Kundor, Unani, Kundur
DOI: https://doi.org/10.31838/ijpr/2018.10.03.015
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