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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Study for The preventive Effects of AjwaDates Alcoholic Extract on TheHepatic Tissue Functions and lipid ProfileRegression Induced byOchratoxin A in Male Albino Rats

Author: DR.ALAAA ALI, DR.SAHER MAHMOOD JWAD
Abstract: The present study designed to investigate the possible efficacy of alcoholic extract of Ajwa fruit to prevent the hepatotoxicity and retrogression of the lipid profile that may be induced by OchratoxinA .This study was carried out in the animal house of Biology department – Faculty of Education for Girls ,forty male rats of strain ( Sprague – Daw ley ) were equally divided into four groups , the control ( first group ) was orally treated with 0.9% of normal saline solution , second group was also orally administrated with Ochratoxin A ( 289 µg / kg ) , the third group was orally received alcoholic extract of Ajwa dates ( 1 mg / kg ) + 289 µg / kg of Ochratoxin A respectively , while the fourth group was subjected to 1 mg / kg of Ajwa dates alcoholic extract + Ochratoxin A at the concentration of 289 µg / kg orally . The treatment of the four groups was once daily for the period of five days weekly. The statistical analysis for the results of present study has been showed a noticeable rise ( P< 0.05 ) in the levels of total cholesterol , triglycerides , low density lipoproteins ( LDL ) very density lipoproteins ( VLDL ) , total bilirubin , whereas a significant reduction ( P< 0.05 ) was revealed in the high density lipoprotein (HDL ) and glutathione levels in the experimental group of laboratory animals that submitted to Ochratoxin A in compared with the other groups of study .With regard to the histological examination for the liver sections of rats that treated with this type of the fungal toxin, several detrimental changes were diagnosed when compared with the othergroups. In the conclusion,Ajwa dates alcoholic extract was alleviated the deteriorative impacts of Ochratoxin A on the hepatic tissues and the lipid profile due to its effective chemical ingredients and potentialities.
Keyword: OchratoxinA , Ajwa ,glutathione.
EOI: http://eoi.citefactor.org/10.11209/ijpr.10.03
DOI: https://doi.org/10.31838/ijpr/2018.10.03.027
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