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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Estimation of Apolipoprotein A, Apo B, Apo E and SomeBiochemical Markers in Type 2 Diabetic Patients in Iraq

Author: HUDA JABER, MOHAMMED ABDULJALIL, HAYDER ALKURAISHY
Abstract: Insulin resistance association with obesity and diabetes is described by rise the plasma TG-rich lipoprotein levels. Apolipoprotein (apo) plays a major role in the lipid metabolism and lipoproteins transport.The study was designed to investigate the levels of several type of Apolipoprotein ( Apo A, Apo B and Apo E) and other biochemical markers in type 2 diabetic patients and their relation with development of diabetic complications.Total of (40) patients of T2DM were selected in the study. For comparison, thirty healthy subject were enrolled in the study. Serum Apo A, Apo B and Apo E was measured. Other biochemical markers also determined which include serum C-peptide, glycosylated hemoglobin, FBS and lipid profile.Type 2 diabetic patients had significantly higher levels of Apo A than matched controls (270±72 vs.160±26 mg/dl, <0.0001), as well as, serum Apo E levels significantly increase in diabetic patients when compare to control group, while serum Apo B considerable higher in patients compared to control but the difference was not statistically significant. Plasma triglycerides were positively and independently correlated with Apo A levels. In conclusion, Apo A and Apo E can be used to follow diabetes and its complications
Keyword: Type 2 diabetes, Apolipoprotein A, Apo B, Apo E , C-peptide
EOI: http://eoi.citefactor.org/10.11209/ijpr.10.03.004
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0.12
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