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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Cardiotonic Activity of Calotropis gigantea Leaf Extract against Doxorubicin Induced Congestive Cardiac Failure in Rats

Author: MOHAMMAD AZAMTHULLA*, ANBU J, ANITA MURALI, NEELAKANTA REDDY
Abstract: Calotropis gigantea is an important medicinal plant widely distributed throughout India. Due to the presence of various phytoconstituents, the present research was focused to evaluate the cardiotonic activity of C. gigantea leaf extract (CGLE) againstDoxorubicin induced cardiac failure. The dried leaf part of C. gigantea was extracted with ethanol and yield was fond to be 10.25% W/W.In-vitro cardiotonic activity of CGLE was studied by using Langendorff’s apparatus. Heart failure is represented by using HRLS and the effect of CGLE was studied by treatingwith different concentrations. In in-vivo study, Doxorubicin (2mg/kg, i.p) for 7 days was usedto induce cardiotoxicity and the protective effect of CGLE at dose 200 and 400 mg/kg wascompared with standard drug Digoxin. The parameters like ECG, serum CPK, SGOT, LDH and Histopathology of Heart tissue were evaluated. Cardiac enzyme & Cytosolic Ca2+ level inCGLE alone treated were studied using dose of 200 and 400 mg/kg daily for 15 days. In In-vitro study, CGLE at 10 mg/ml showed a significant increase in force ofcontraction, cardiac output and heart rate in the failing heart. In-vivo study revealed thatCGLE 400 mg/kg showed more significant protection by decrease in RR and QT intervals in ECG, serum CPK, SGOT and LDH levels were significantly reduced and histopathologicalstudies showed improvement myocardial tissue. Treatment with CGLE alone doesn’t showed increase cardiac enzyme & cytosolic Ca2+ level. Thus the study revealed that C.gigantea leaf extract possess significant cardiotonic activity against doxorubicin inducedheart failure.
Keyword: Cardiotonic activity, C.Gigantea, Doxorubicin, Heart failure
EOI: http://eoi.citefactor.org/10.11209/ijpr.10.03.005
DOI: https://doi.org/10.31838/ijpr/2018.10.03.034
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