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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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ANTI-BIOFILM ACTIVITY OF TERMINALIA CHEBULA FRUITS AGAINST ORAL PATHOGENS

Author: S.AISHA SITHIKA,, A.RENUKA, D.SHANMUGASUNDAR, ANEESH NAIR, FLORIDA TILTON
Abstract: Dental caries is a common oral bacterial pathology caused by a biofilm consisting of microorganisms present on the tooth surface.Biofilm is an association of micro-organisms in which microbial cells adhere to each other on a living or non-living surface within a self-produced matrix of extracellular polymeric substance. During biofilm formation many species of bacteria are able to communicate with one another through specific mechanism called quorum sensing.Bacterial biofilm is less accessible to antibiotics and human immune system and thus poses a big threat to public health because of its involvement in variety of infectious diseases.This paper is designated to evaluate the antibacterial activity of three solvent extracts of Terminalia chebula fruits against oral pathogens. The biofilm formation assay was carried out by Crystal violet assay.The antibacterial activities were assessed by agar well diffusion.Antibiofilm activity was investigated by Crystal Violet assay.Ethyl acetate and Ethanol extracts of Terminalia chebula showed the best antibacterial activities against both the strains in the minimal inhibitory concentration ranged from 20-100 µg/mL .Killing ability depended on time and concentrations of the extract. Terminalia chebula acts as a potent antibiofilm agent with dual actions, preventing and eradicating the biofilm. The major constituent of Terminalia chebula extract was ethanol, which responded for antibacterial and antibiofilm against oral pathogens. It suggests that the ethanol Terminalia chebula extract may be used for preventing dental plaques.
Keyword: Biofilms,T.chebula, oral pathogens, Crystal Violet Assay, phytochemical analysis
EOI: http://eoi.citefactor.org/10.11209/ijpr.10.03.009
DOI: https://doi.org/10.31838/ijpr/2018.10.03.036
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