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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Evaluation of Zingiber officinale Effects on Rifampicin Pharmacokinetic Parameters Using Animal Model

Author: EBERE EMILIA, AYOGU, KOSISOCHI CHINWENDU AMORHA, OLUCHUKWU OKPALAOKA, MATHEW JEGBEFUME OKONTA
Abstract: The effect of ginger extract on the pharmacokinetic parameters of rifampicin and its penetration into the lung was investigated. Fifteen albino rats were divided into three groups. Group A received rifampicin 10 mg/kg alone orally; Groups B and C received 5 and 10 mg/kg of ginger extract, respectively, for 10 days and on day 11, they received 10 mg/kg rifampicin as in group A. Blood samples were collected at different time intervals and assayed. Treatment with 5 mg/kg ginger significantly (p=0.03) increased Tmax by 93 % and decreased t1/2 by 72% (p=0.04), with a non-significant decrease in Cmax, by 18 %, while treatment with 10 mg/kg ginger resulted in a significant decrease in t1/2 (p=0.02) 59 % with a non-significant (p=0.67) increase in Tmax by 7 %, decrease in Cmax, and AUC, by 8 and 5 % respectively. Concurrent administration of ginger and rifampicin resulted in significant decrease (p=0.04) in the concentration of rifampicin that penetrated the lung from 14.63±4.06 in rifampicin alone to 9.99±4.06 and 9.14±0.97 for 5 and 10 mg/kg ginger. This study reported that ginger caused significant change in the pharmacokinetic parameters of rifampicin when taken concurrently and also decreased concentration of rifampicin in the lungs.
Keyword: Ginger, Rifampicin, Pharmacokinetics, Lung penetration
EOI: http://eoi.citefactor.org/10.11209/ijpr.10.03.011
DOI: https://doi.org/10.31838/ijpr/2018.10.03.039
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