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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Effect of experimentally induced hypothyroidism on some renal functions in male rats

Author: ENNAS MAJHWOL*, WEJDAN MATROOD KADHEM
Abstract: studies have shown that dysfunction in thyroid function results in impaired kidney function , the objective of this study was to define to effects of hypothyroidism on serum levels of urea , creatinine , uric acid and electrolytes , this study also investigated the effect of vitamin C supplementationon thyroid hormones and renal functions in rats with hypothyroidism . 30 male rats were divided into 3 groups including: G1: N=10 (control rats dose the physiological solution Na 0.9%) , G2: N=10 ( hypothyroidism rats were induced by dose 0.04% methimazole , G3 : N=10 (hypothyroidism rats supplemented with 200 mg/kg/day of vitamin C) , blood samples were collectedfrom each rat and were centrifugation to obtain serum, methimazole exposed rats showed hypothyroidism with significant (P<0.05) decrease in levels of T3 and T4 with significant (P<0.05) increase in concentration of TSH in serum , hypothyroidism group also showed a rise in the levels of urea , creatinine and uric acid, compared to control group , on the other hand, hypothyroidism supplemented with vitamin C group result in the showed marked improvement in thyroid hormone levels ,urea , creatinine , uric acid and electrolytes and their comparison of control group ,might be due to their antioxidant properties. it could be suggested that hypothyroidism resulting from decline of thyroid hormones and vitamin C could be used as suitable supplementation therapy for hypothyroidism patients , vitamin C supplementation remarkably reduce methimazole induced hypothyroidism effects on renal dysfunction , this may provide insight into the possible potential renal protective effect of vitamin C supplementation against hypothyroidism. .
Keyword: hypothyroidism , renal dysfunction , vitamin C , rats
EOI: http://eoi.citefactor.org/10.11209/ijpr.10.03
DOI: https://doi.org/10.31838/ijpr/2018.10.03.045
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